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New or unexpected symptoms : Whilst rare, allergic reactions to hydroxocobalamin can occur

Another component of the vitamin B complex, riboflavin (B2), protects the skin by increasing cell turnover and assisting collagen maintenance, while niacin (B3) helps alleviate common skin issues like acne, eczema, dermatitis, rosacea, wrinkles and damaged skin in general

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In a 2013 study tinnitus patients with low B12 vitamin levels, audiometric tests conducted after B12 vitamin treatment revealed a significant improvement in hearing levels

Early evidence for the potential efficacy of this route was published in 1999, where 18 patients with B12 deficiency treated exclusively with 712 days of 2 mg of sublingual cobalamin daily had 4 times higher B12 levels compared to pre-treatment, reaching therapeutic ranges ( There have also been further studies comparing treatment outcomes from the sublingual route to the more established IM and oral routes

No serious systemic side effects have been documented in peer-reviewed studies at therapeutic doses